Oregon Grape, aka Berberis Aquifolium, is known for its yellow roots, holly-like leaves, and tart, blue berries that resemble a cluster of grapes. Oregon Grape is a member of the Berberidaceae family and its roots contain the chemical constituent berberine, thought to be responsible for many of the plant’s healthful benefits. A suitable substitute for goldenseal, Oregon Grape Root can be extracted, added to herbal tea blends, and employed in topical care formulas.